This annual lectureship highlights a female physician-scientist, who will discuss her scientific journey, including personal and professional opportunities and challenges that shaped her path to a rewarding research career. Christine Seidman is the Thomas W. Smith Professor of Medicine and Genetics at Harvard Medical School, an investigator of the Howard Hughes Medical Institute, and Director of the Cardiovascular Genetics Service at Brigham and Women’s Hospital. Dr. Seidman has pioneered the discovery of the genetic basis for heart muscle disorders, including hypertrophic and dilated cardiomyopathies and congenital heart disease. By engineering human mutations into iPSC-derived cardiomyocytes and mouse models she has identified molecular mechanisms and therapeutic targets. Her work has enabled development of clinical gene-based diagnostics, early and accurate identification of at-risk individuals, and pre-emptive interventions to limit the progression and devastating outcomes associated with these disorders.