CAMRIS is a clinical and life sciences firm that realizes innovative solutions to challenges worldwide through high-quality, cost-effective program and research management services. We combine our proven systems with today’s most effective, evidence-based best practices to improve the lives of people around the world. Our core practice areas include HIV/AIDS, microbiology and infectious disease research, vaccine research, development and production, global health security, biodefense, and clinical research.
CAMRIS attracts the next generation of scientists to work at premier government research and development institutions with state-of-the-art facilities and equipment, under world leaders in health research. Our exceptional benefits package that includes medical, dental and vision coverage, 401k plan with employer contribution, paid holidays, vacation, Medical and Flexible Spending Accounts, and life insurance. If you enjoy being a part of a high performing health and research organization dedicated to making the world a healthier place, please apply today!
We are seeking a Scientist to support the overall functions of the Vaccine Production Program at the Vaccine Research Center, NIH:
* Advance vaccine and therapeutic protein candidates including monoclonal antibodies, recombinant proteins, and virus-like particles for preclinical development programs.
* Participate in cell line development platform design, optimization, and cycle-time reduction studies including methods for clone selection, expansion, ranking, and characterization by reviewing recent literature and new technologies.
* Independently plan and execute small-scale process development studies using various culture vessels including tissue culture plates, shake flasks, and small-scale bioreactors.
* Contribute to expression vector design and optimization studies utilizing knowledge of molecular biology techniques.
* Identify, propose, and execute process and procedural changes to improve process performance, robustness, productivity, and efficiency.
* Prepare plasmid DNA using standard molecular cloning techniques.
* Perform transfection, selection, and maintenance of cells expressing proteins of interest.
* Generate and evaluate recombinant CHO cell lines using automated platforms for clone selection and screening.
* Generate, maintain and review accurate daily records of experiments and results in a laboratory notebook.
* Prepare and review experimental plans, proposals, reports, SOPs, and production records.
* Collect information, draft and verify data for CMC sections of pre-IND and IND documents to ensure successful registration of candidates.
* Review experiments in order to evaluate the progress of the research and ensure that experiments and documentation conform to established protocols.
* Work closely with other members of CLD team, upstream process development and downstream process development teams to improve workflow efficiency and overall process yield.
* Ensure timely completion of lab cleaning, equipment maintenance, and supply ordering by team members.
* Work with team director to manage project timelines and provide regular updates to project teams.
* Coordinate team meeting updates and presentations.
* Ph.D. in Biological Sciences with a minimum of 2 years of independent research experience in an academic or industrial setting or M.S. in Biological Sciences with a minimum of 5 years of experience.
* Hands-on experience with aseptic technique and mammalian cell culture along with supporting technologies for cell line engineering including cell counting, high-throughput transfection, single-cell cloning, and flow cytometry.
* Familiarity with molecular cloning methods, PCR, and agarose gel electrophoresis.
* Ability to independently design experiments and work plans and manage project timelines for complex projects.
* Experience in preparing technical reports, standard operating procedures, and data presentations.
* Ability to work in a collaborative environment within the cell line development team and with other teams.