The Immuno-Oncology Research Group is seeking to fill a post-doctoral position with a highly qualified, innovative, “outside of the box” thinking and collaborative candidate. The successful candidate will pursue research that seeks to dissect the anti-tumor T cell response. The aim of the study is to generate new findings that will lead to developing innovative and effective targeted therapeutic strategies. The results of this research will be communicated by published outcomes in high-impact journals. We are seeking candidates with experience in immunology, molecular biology, flow cytometry, cell culture work and preclinical tumor models. Self-motivated and creative individuals with a track record in the field of immunology/tumor immunology and/or oncology, with relevant publications and an interest in translational opportunities should apply. Successful candidates should have excellent written and oral communication skills.
Independently design, plan, and perform complex anti-tumor efficacy studies in mice including dosing (IV, SC, IP) and tumor growth monitoring.
Dissection of tumors / organs for immune cell isolation and subsequent analysis.
Design flow cytometry (FACS) complex panels and perform FACS analysis on immune cells isolated from tumors and tissues.
Analyze data using biological and statistical software such as Flowjo, Prism, Excel, etc.
Collaborate closely with cross-functional teams across the company.
Manage multiple projects simultaneously.
Synthesize results across experiments and programs in PowerPoint presentations and present to multi-disciplinary colleagues and senior management, including clinical teams.
Document experimental procedures and results in a well-organized fashion; generate experimental reports.
Participate in general lab duties of the team.
Participate in post-doctoral program activities (e.g., weekly meetings and annual research conference)
Work successfully in cross-functional teams by contributing data and ideas
Continuously stay updated with latest relevant literature, attend scientific meetings and maintain expertise in the field of Immunology and Immuno-Oncology
Additionally, the successful candidate should be receptive to novel technologies to increase work efficiency, optimization of current protocols and development of new techniques.
Doctoral degree in a relevant discipline
Scientist looking for his/her first or second postdoctoral training
Superior scientific skills including critical and analytical thinking
Demonstrated publication success as evidenced by peer-reviewed publications
Ability to interact dynamically and constructively with scientific peers
Occasional travel for conferences
Technical Skills Required:
– Expertise with animal handling is a must; experienced in different methods of compound administration (i.v., i.p., s.c., etc), and tissue /sample collection.
Ability to design and perform complex in vivo experiments utilizing tumor models in mice.
– Experienced in isolation and characterization of primary immune cells from murine tissues/tumors and human blood.
– Experienced in cell culture (both primary cells and established cell lines) and transfection; experience with viral transduction is a plus.
– Extensive knowledge and practical experience with advanced flow cytometry is a must, including complex panel design for cell surface and intracellular staining, data acquisition and analysis.
Skilled in a variety of in vitro/ex vivo immune cell-based assays, including planning, execution, analysis and record keeping.
Experience with T cells, DC/macrophage-based functional assays is highly preferred.
Experience with RNAseq and/or single cell RNAseq experimentation is highly preferred.
Expertise in cellular and molecular immunology
Strong organizational and time-management skills including the ability to handle multiple tasks simultaneously and prioritize.
Demonstrated creativity and independency.
Ability to effectively collaborate as part of cross-functional teams.
Clear and professional verbal and written communication.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!