Alicia Little, MD, PhD, is seeking a Postgraduate Associate for a position in her laboratory in the Department of Dermatology at the Yale School of Medicine. Dr. Little’s laboratory is located within the laboratory of Joseph Craft, MD, Professor of Medicine and Immunobiology, and the Postgraduate Research Associate will have mentorship and resources provided by both principal investigators.
The ideal candidate has majored in the Biological or Chemical Sciences but has not yet received a doctoral degree and is seeking advanced scientific training for a duration of 1 year. A second year of training may be possible. This is an ideal position for an individual interested in subsequent graduate training, such as an MD, PhD, or MD/PhD. Prior laboratory-based and/or clinical research experience is a plus but not required. Candidates with graduate training (PhD, MD, or other doctorate) are not eligible.
As a Postgraduate Associate, the candidate will perform basic science and/or translational research related to two ongoing projects: 1) characterizing immune cells from skin and blood in human cutaneous lupus patients as well as in mouse models of lupus and 2) developing and testing pathogenesis-targeted therapies for cutaneous and systemic lupus. The projects employ a broad range of techniques in the lab including disease modeling, molecular and cellular biology, single-cell RNA sequencing, and other new tissue-based approaches.
The candidate will meet at least twice weekly with Dr. Little, and s/he will have opportunities to present his/her data at intramural and/or national/international conferences, should this be of interest. The overall goal is to gain experience in designing and performing both basic and translational scientific work that can be used as a foundation for a future career in science and/or medicine. In addition, the candidate will be given career development opportunities (e.g. scientific writing and public speaking skills) that are individually tailored to her/his long-term career goals. The ultimate goal is to create an experience that is rewarding and engaging for the successful applicant and to foster scientific, professional, and/or educational advancement.
Anticipated activities for the candidate would include some or all of the following:
– Basic molecular biology techniques such as quantitative PCR and Western blots
– Immunohistochemical stains of tissue followed by visualization using various microscopy techniques including confocal microscopy and basic immunofluorescence/brightfield microscopy
– Preparation of mouse and human tissues for bulk and single-cell RNA sequencing as well as for fluorescence-activated cell sorting (FACS) and analysis
– Assist with mouse colony management, husbandry and genotyping
– Basic tissue culture techniques
– Use basic software/statistical tools such as Adobe Photoshop, Illustrator, Fiji, etc. Opportunity to develop advanced programming/data analysis skills if desired.
– Assist with data analysis, interpretation, and generation of figure quality data for publication and/or presentations
– Attend conferences where he/she can network and/or present research data
– Attend weekly dermatology and immunology research in progress conferences interest as well as weekly lab meetings
– Assist with shipment of samples
– Assist with writing scientific papers, case reports, and reviews, if of interest
Interested candidates should submit a cover letter that briefly describes their personal and career goals as well as their research/scientific background, their CV, and at least 3 names of references.
Position will start summer 2021. Applications will be reviewed in a rolling manner.